Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice.

International journal of cancer - 15 Aug 2016

Ren Mingqiang, Qin Haiyan, Wu Qing, Savage Natasha M, George Tracy I, Cowell John K

Abstract excerpt

Acute myelogenous leukemia (AML) has an overall poor survival rate and shows considerable molecular heterogeneity in its etiology. In the WHO classification there are >50 cytogenetic subgroups of AML, many showing highly specific chromosome translocations that lead to constitutive activation of individual kinases. In a rare stem cell leukemia/lymphoma syndrome, translocations involving 8p11 lead to constitutive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD34
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterografts

Share to Immunocompromised Host

Share to Immunophenotyping

Share to Kruppel-Like Factor 4

Share to Oncogene Proteins, Fusion

Share to Receptor, Fibroblast Growth Factor, Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 27005999
DOI: 10.1002/ijc.30100
PMCID: PMC5754922

Genes

FGFR1
ZMYM2
FLT3
KLF4
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice.PMID 27005999Read ↗

A model of BCR ‐ FGFR 1 driven human AML in immunocompromised miceSemantic proximity Read ↗

Advances in the development of animal models of myeloid leukemias.Semantic proximity Read ↗

Murine models of human acute myeloid leukemia.Semantic proximity Read ↗

Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models.Semantic proximity Read ↗

Targeting FGFR1 to suppress leukemogenesis in syndromic and <i>de novo</i> AML in murine modelsSemantic proximity Read ↗

MLL leukemia induction by genome editing of human CD34+ hematopoietic cellsSemantic proximity Read ↗

A Critical Review of Animal Models Used in Acute Myeloid Leukemia PathophysiologySemantic proximity Read ↗

Murine Models of Acute Myeloid LeukaemiaSemantic proximity Read ↗

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model.Semantic proximity Read ↗

Zebrafish models of acute leukemias: Current models and future directions.Semantic proximity Read ↗

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft modelsSemantic proximity Read ↗

A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative NeoplasmsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.