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Article

Spatially constrained gene regulation identifies key genetic contributions of preeclampsia, hypertension, and proteinuria†.

Biology of reproduction - 11 Apr 2023

Boom Genevieve, O'Sullivan Justin M, Schierding William

Abstract excerpt

Preeclampsia (PE) is a relatively common but severe pregnancy disorder (with very limited effective treatments) characterized by hypertension (HTN) and usually proteinuria (PRO) or other organ damage. Genome-wide association studies (GWAS) of PE, HTN, and PRO have mostly identified risk loci single nucleotide polymorphisms (SNPs) located in noncoding genomic regions, likely impacting the regulation of distal gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36738257
DOI: 10.1093/biolre/ioad016
PMCID: PMC10106839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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