Article
Sample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression.
Nature communications - 2 Feb 2023
Yu Qing, Liu Xinyue, Keller Mark P, Navarrete-Perea Jose, Zhang Tian, Fu Sipei, Vaites Laura P, Shuken Steven R, Schmid Ernst, Keele Gregory R, Li Jiaming, Huttlin Edward L, Rashan Edrees H, Simcox Judith, Churchill Gary A, Schweppe Devin K, Attie Alan D, Paulo Joao A, Gygi Steven P
Abstract excerpt
Targeted proteomics enables hypothesis-driven research by measuring the cellular expression of protein cohorts related by function, disease, or class after perturbation. Here, we present a pathway-centric approach and an assay builder resource for targeting entire pathways of up to 200 proteins selected from >10,000 expressed proteins to directly measure their abundances, exploiting sample multiplexing to...
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