Article
A large-scale genome-lipid association map guides lipid identification.
Nature metabolism - 1 Oct 2020
Linke Vanessa, Overmyer Katherine A, Miller Ian J, Brademan Dain R, Hutchins Paul D, Trujillo Edna A, Reddy Thiru R, Russell Jason D, Cushing Emily M, Schueler Kathryn L, Stapleton Donald S, Rabaglia Mary E, Keller Mark P, Gatti Daniel M, Keele Gregory R, Pham Duy, Broman Karl W, Churchill Gary A, Attie Alan D, Coon Joshua J
Abstract excerpt
Despite the crucial roles of lipids in metabolism, we are still at the early stages of comprehensively annotating lipid species and their genetic basis. Mass spectrometry-based discovery lipidomics offers the potential to globally survey lipids and their relative abundances in various biological samples. To discover the genetics of lipid features obtained through high-resolution liquid chromatography-tandem mass...
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