Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetically downregulated Interleukin-6 signalling is associated with a lower risk of frailty

1 Jan 2023

Abstract excerpt

BACKGROUND: numerous studies point towards a critical role of Interleukin 6 (IL-6) pathway in frailty pathogenesis yet the causal relationship between the two remains elusive. METHODS: we selected genetic variants near the IL-6 receptor locus (IL-6R) associated with reduced C-reactive protein (CRP) levels, a downstream effector of IL-6 pathway, and we used them as genetic proxies of IL-6 signalling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Frailty in Older Adults
Share to Genetics, Aging, and Longevity in Model Organisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36729470
DOI: 10.1093/ageing/afac318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetically downregulated Interleukin-6 signalling is associated with a lower risk of frailtyPMID 36729470Read ↗

Dissecting the IL-6 pathway in cardiometabolic disease: A Mendelian randomization study on both IL6 and IL6R.Semantic proximity Read ↗

A genome‐wide association study of the frailty index highlights brain pathways in ageingSemantic proximity Read ↗

Genetically downregulated interleukin-6 signaling is associated with a favorable cardiometabolic profile: a phenome-wide association studySemantic proximity Read ↗

The causal association between circulating cytokines with the risk of frailty and sarcopenia under the perspective of geroscience.Semantic proximity Read ↗

A Genome-Wide Association Study of the Frailty Index Highlights Synaptic Pathways in AgingSemantic proximity Read ↗

CRP 1846G>A polymorphism increases risk of frailty.Semantic proximity Read ↗

A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways.Semantic proximity Read ↗

Unraveling the relationship between high-sensitivity C-reactive protein and frailty: evidence from longitudinal cohort study and genetic analysisSemantic proximity Read ↗

IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic riskSemantic proximity Read ↗

Genetic insights into the causal linkage between systemic inflammatory regulators and frailty.Semantic proximity Read ↗

Association of shorter leucocyte telomere length with risk of frailtySemantic proximity Read ↗

Altered immune system in frailty: Genetics and diet may influence inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.