Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRP 1846G>A polymorphism increases risk of frailty.

Maturitas - 1 Mar 2012

Almeida Osvaldo P, Norman Paul E, van Bockxmeer Frank M, Hankey Graeme J, Flicker Leon

Abstract excerpt

BACKGROUND: Frailty is a syndrome characterized by diminished ability to re-establish homeostasis in response to stress. We hypothesized that deficient allostatic responses to physiological challenges may predispose to frailty, that C-reactive protein (CRP) and its genetic determinants may be a measure of the integrity of the allostatic response, and that genetic determinants of the allostatic response determine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Australia
Share to C-Reactive Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross-Sectional Studies

Share to Frail Elderly

Share to Life Style

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 22192441
DOI: 10.1016/j.maturitas.2011.11.022

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRP 1846G>A polymorphism increases risk of frailty.PMID 22192441Read ↗

Association of CRP gene polymorphisms with CRP levels, frailty and co-morbidity in an elderly Chinese population: results from RuLAS.Semantic proximity Read ↗

Unraveling the relationship between high-sensitivity C-reactive protein and frailty: evidence from longitudinal cohort study and genetic analysisSemantic proximity Read ↗

Genetically downregulated Interleukin-6 signalling is associated with a lower risk of frailtySemantic proximity Read ↗

Altered immune system in frailty: Genetics and diet may influence inflammationSemantic proximity Read ↗

Biology of frailty: Modulation of ageing genes and its importance to prevent age-associated loss of function.Semantic proximity Read ↗

Frailty and genetics: linking molecular aging to clinical vulnerability.Semantic proximity Read ↗

Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses.Semantic proximity Read ↗

Genetic variant of Interleukin-18 gene is associated with the Frailty Index in the English Longitudinal Study of Ageing.Semantic proximity Read ↗

Frailty phenotype as mediator between systemic inflammation and osteoporosis and fracture risks: A prospective study.Semantic proximity Read ↗

Frailty and the older man.Semantic proximity Read ↗

Proinflammatory genotype is associated with the frailty phenotype in the English Longitudinal Study of Ageing.Semantic proximity Read ↗

Characterization of the plasma proteomic profile of frailty phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.