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Genetic insights into the causal linkage between systemic inflammatory regulators and frailty.

Cytokine - 1 Dec 2024

Guo Xingzhi, Zhou Rong, Tian Ge, Shi Wenzhi, Lu JuanJuan, Li Rui

Abstract excerpt

OBJECTIVES: Previous studies have suggested the associations between systemic inflammation and the risk of frailty, but causal relationships between them remain not well established. We conducted a bi-directional Mendelian randomization (MR) analysis to investigate the causal links between systemic inflammatory regulators and frailty. METHODS: Genetic variants associated with systemic inflammatory regulators were...

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Chemokine CCL4
Cytokines
Frailty
Inflammation
Interleukin-4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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PMID: 39447338
DOI: 10.1016/j.cyto.2024.156791

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MIP

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