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Article

Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary.

EMBO molecular medicine - 8 Mar 2023

Brundu Serena, Napolitano Virginia, Franzolin Giulia, Lo Cascio Ettore, Mastrantonio Roberta, Sardo Gabriele, Cascardi Eliano, Verginelli Federica, Sarnataro Sergio, Gambardella Gennaro, Pisacane Alberto, Arcovito Alessandro, Boccaccio Carla, Comoglio Paolo M, Giraudo Enrico, Tamagnone Luca

Abstract excerpt

The genetic changes sustaining the development of cancers of unknown primary (CUP) remain elusive. The whole-exome genomic profiling of 14 rigorously selected CUP samples did not reveal specific recurring mutation in known driver genes. However, by comparing the mutational landscape of CUPs with that of most other human tumor types, it emerged a consistent enrichment of changes in genes belonging to the axon...

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Source

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Identifiers

PMID: 36722641
DOI: 10.15252/emmm.202216104
PMCID: PMC9994481

Genes

EGFR
PLXNB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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