Article

Stem-like cells from Cancer of Unknown Primary are endowed with distinctive hypermetastatic properties and unveil liability to MEK inhibition

2020-07-28

Abstract excerpt

<title>Abstract</title> <p>Cancers of Unknown Primary (CUPs), featuring metastatic dissemination in the absence of a primary tumor, are a biological enigma and a fatal disease. We propose that CUPs are a distinct, yet unrecognized, pathological entity originating from stem-like cells endowed with unique properties. These cells can be isolated in vitro (agnospheres) and propagated in vivo by serial transplantation...

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Literature Corpus work: d7fee4ec-cc4f-5051-8905-838e63057db1
DOI: 10.21203/rs.3.rs-45580/v1

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