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Article

APOE ε4 is associated with earlier symptom onset in LOAD but later symptom onset in EOAD.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2023

Polsinelli Angelina J, Lane Kathleen A, Manchella Mohit K, Logan Paige E, Gao Sujuan, Apostolova Liana G

Abstract excerpt

BACKGROUND: We studied the effect of apolipoprotein E (APOE) ε4 status and sex on age of symptom onset (AO) in early- (EO) and late- (LO) onset Alzheimer's disease (AD). METHOD: A total of 998 EOAD and 2562 LOAD participants from the National Alzheimer's Coordinating Center (NACC) were included. We used analysis of variance to examine AO differences between sexes and APOE genotypes and the effect of APOE ε4, sex,...

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Identifiers

PMID: 36722399
DOI: 10.1002/alz.12955
PMCID: PMC10182241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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