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Article

Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis.

The Journal of investigative dermatology - 1 Jul 2023

Marusina Alina I, Ji-Xu Antonio, Le Stephanie T, Toussi Atrin, Tsoi Lam C, Li Qinyuan, Luxardi Guillaume, Nava Jordan, Downing Lauren, Leal Annie R, Kuzminykh Nikolay Y, Kruglinskaya Olga, Brüggen Marie-Charlotte, Adamopoulos Iannis E, Merleev Alexander A, Gudjonsson Johann E, Maverakis Emanual

Abstract excerpt

ERAP1, ERAP2, and LNPEP are aminopeptidases implicated in autoimmune pathophysiology. In this study, we show that ERAP2 is upregulated and ERAP1 is downregulated in patients with psoriasis who are homozygous for autoimmune-linked variants of ERAP. We also demonstrate that aminopeptidase expression is not uniform in the skin. Specifically, the intracellular antigen-processing aminopeptidases ERAP1 and ERAP2 are...

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Identifiers

PMID: 36716917
DOI: 10.1016/j.jid.2023.01.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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