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Germline excision of transgenes in Aedes aegypti by homing endonucleases

3 Apr 2013

Abstract excerpt

Aedes (Ae.) aegypti is the primary vector for dengue viruses (serotypes1-4) and chikungunya virus. Homing endonucleases (HEs) are ancient selfish elements that catalyze double-stranded DNA breaks (DSB) in a highly specific manner. In this report, we show that the HEs Y2-I-AniI, I-CreI and I-SceI are all capable of catalyzing the excision of genomic segments from the Ae. aegypti genome in a heritable manner....

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PMID: 23549343
DOI: 10.1038/srep01603

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