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The Presence of Typical "BRAFV600E-Like" Atypia in Papillary Thyroid Carcinoma is Highly Specific for the Presence of the BRAFV600E Mutation.

Endocrine pathology - 1 Mar 2023

Turchini John, Sioson Loretta, Clarkson Adele, Sheen Amy, Delbridge Leigh, Glover Anthony, Sywak Mark, Sidhu Stan, Gill Anthony J

Abstract excerpt

Papillary thyroid carcinomas (PTCs) are driven by a variety of molecular abnormalities including BRAF, RAS, ALK, RET, and NTRK alterations. PTCs driven by the BRAFV600E mutation, or tumours which demonstrate a similar gene expression profile to PTCs driven by this mutation, have been reported to demonstrate specific morphological features sometimes termed "BRAFV600E-like" atypia. BRAFV600E-like atypia is...

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PMID: 36709221
DOI: 10.1007/s12022-022-09747-9

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