Article
BRAF mutation detection in indeterminate thyroid cytology specimens: underlying cytologic, molecular, and pathologic characteristics of papillary thyroid carcinoma.
Cancer cytopathology - 1 Apr 2013
Ohori N Paul, Singhal Rashi, Nikiforova Marina N, Yip Linwah, Schoedel Karen E, Coyne Christopher, McCoy Kelly L, LeBeau Shane O, Hodak Steven P, Carty Sally E, Nikiforov Yuri E
Abstract excerpt
BACKGROUND: BRAF mutations are highly specific for papillary thyroid carcinoma (PTC) and many cytology specimens with BRAF mutations are expected to demonstrate cytologic features typical of PTC. However, indeterminate thyroid cytology cases are inevitable and understanding the significance of the BRAF mutation within the context of the Bethesda System for Reporting Thyroid Cytopathology would be valuable....
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