Article
Are there specific cytologic features that can predict BRAFV600E mutational status of papillary thyroid carcinoma in fine-needle aspiration specimens?
Diagnostic cytopathology - 1 Jun 2024
Mendes Juliann M, Elsheikh Tarik M, Di Marco Jessica, Russell Jennifer, Gladkaya Tatyana, Nicolas Marlo M, Clapacs Elisha, Bena James F, McAfee John L, Policarpio-Nicolas Maria Luisa C
Abstract excerpt
BACKGROUND: BRAFV600E mutation is the most common molecular alteration found in papillary thyroid carcinoma (PTC) and has been linked to recurrent disease or possibly more aggressive behavior. Some studies have reported sickle-shaped nuclei (SSN) and plump pink cells (PPC) to be predictive markers of BRAF mutation in FNA cytology. We aimed to evaluate the reproducibility of the aforementioned cytologic features....
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