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Suppression of viral RNA polymerase activity is necessary for persistent infection during the transformation of measles virus into SSPE virus

26 Jul 2023

Abstract excerpt

Subacute sclerosing panencephalitis (SSPE) is a fatal neurodegenerative disease caused by measles virus (MV), which typically develops 7 to 10 years after acute measles. During the incubation period, MV establishes a persistent infection in the brain and accumulates mutations that generate neuropathogenic SSPE virus. The neuropathogenicity is closely associated with enhanced propagation mediated by cell-to-cell...

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PMID: 37494386
DOI: 10.1371/journal.ppat.1011528

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