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Human and animal morbillivirus strains causing chronic neurological infections share key genotypic and phenotypic traits.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jul 2026

Daniel Roji Melvin, Geiselhardt Franziska, Beythien Georg, Laudeley Kristin, Mirolo Monica, Jo Wendy K, Martino Laura, Beineke Andreas, Baumgärtner Wolfgang, Peters Martin, van den Brand Judith M A, Jensen Trine H, Kuiken Thijs, Langedijk Johannes P M, Domingo Mariano, Osterhaus Albert D M E, Ludlow Martin

Abstract excerpt

Long-term persistent measles virus (MeV) infection of the central nervous system (CNS) can result in subacute sclerosing panencephalitis (SSPE), an invariably fatal late neurological complication of measles. Analogous SSPE-like chronic diseases have also been reported in adult dogs, cetaceans, and more recently harbor seals following infection by canine distemper virus (CDV), dolphin morbillivirus (DMV), and...

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PMID: 42412932
DOI: 10.1073/pnas.2604205123
PMCID: PMC13367801

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