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Article

CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction.

JAMA network open - 3 Jan 2023

Mahdavi Sara, Palatini Paolo, El-Sohemy Ahmed

Abstract excerpt

Importance: Caffeine is detoxified by cytochrome P450 1A2 (CYP1A2), and genetic variation in CYP1A2 impacts the rate of caffeine clearance. Factors that may modify the association between coffee intake and kidney disease remain unclear. Objective: To assess whether CYP1A2 genotype modifies the association between coffee intake and kidney dysfunction. Design, Setting, and Participants: The Hypertension and...

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Identifiers

PMID: 36701157
DOI: 10.1001/jamanetworkopen.2022.47868
PMCID: PMC9880799

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