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Article

Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank.

JAMA internal medicine - 1 Aug 2018

Loftfield Erikka, Cornelis Marilyn C, Caporaso Neil, Yu Kai, Sinha Rashmi, Freedman Neal

Abstract excerpt

Importance: Prospective cohorts in North America, Europe, and Asia show consistent inverse associations between coffee drinking and mortality, including deaths from cardiovascular disease and some cancers. However, concerns about coffee, particularly among people with common genetic polymorphisms affecting caffeine metabolism and among those drinking more than 5 cups per day, remain. Objective: To evaluate...

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PMID: 29971434
DOI: 10.1001/jamainternmed.2018.2425
PMCID: PMC6143111

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