Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension.

doi:10.1093/hmg/dds137

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Article

Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension.

Human molecular genetics - 15 Jul 2012

Guessous Idris, Dobrinas Maria, Kutalik Zoltán, Pruijm Menno, Ehret Georg, Maillard Marc, Bergmann Sven, Beckmann Jacques S, Cusi Daniele, Rizzi Federica, Cappuccio Franco, Cornuz Jacques, Paccaud Fred, Mooser Vincent, Gaspoz Jean-Michel, Waeber Gérard, Burnier Michel, Vollenweider Peter, Eap Chin B, Bochud Murielle

Abstract excerpt

The 15q24.1 locus, including CYP1A2, is associated with blood pressure (BP). The CYP1A2 rs762551 C allele is associated with lower CYP1A2 enzyme activity. CYP1A2 metabolizes caffeine and is induced by smoking. The association of caffeine consumption with hypertension remains controversial. We explored the effects of CYP1A2 variants and CYP1A2 enzyme activity on BP, focusing on caffeine as the potential mediator...

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PMID: 22492992
DOI: 10.1093/hmg/dds137

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