Coffee intake, genetic variants, and chronic kidney disease: a cross-sectional analysis of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study.

doi:10.1007/s00394-025-03819-2

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Article

Coffee intake, genetic variants, and chronic kidney disease: a cross-sectional analysis of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study.

European journal of nutrition - 15 Oct 2025

Unohara Taichi, Fujii Ryosuke, Watanabe Takeshi, Matsuura Akari, Torii Yuka, Kita Kahori, Ishizu Masashi, Hara Megumi, Nishida Yuichiro, Nagayoshi Mako, Matsunaga Takashi, Okada Rieko, Kubo Yoko, Tanoue Shiroh, Hidaka Yoshifumi, Nishiyama Takeshi, Nakagawa-Senda Hiroko, Koyama Teruhide, Watanabe Isao, Kuriki Kiyonori, Takashima Naoyuki, Kondo Keiko, Nakatochi Masahiro, Momozawa Yukihide, Tamura Takashi, Matsuo Keitaro

Abstract excerpt

PURPOSE: The present study aimed to clarify associations between coffee intake and kidney function with consideration of the effect modifications from coffee intake-related genetic polymorphisms. METHODS: This cross-sectional study included 7,468 Japanese participants 35-69 years old (3,953 women: 52.9%) from the baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Coffee intake was...

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Topics

Humans
Coffee
Female
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cross-Sectional Studies

Male

Renal Insufficiency, Chronic

Japan

Aged

Polymorphism, Single Nucleotide

Adult

Glomerular Filtration Rate

Cohort Studies

Cytochrome P-450 CYP1A2

Basic Helix-Loop-Helix Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 41094118
DOI: 10.1007/s00394-025-03819-2
PMCID: PMC12528254

Genes

AHR
CYP1A2
HECTD4

Provenance

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