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HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion Site

25 Apr 2021

Abstract excerpt

Hepatitis B virus (HBV), one of the well-known DNA oncogenic viruses, is the leading cause of hepatocellular carcinoma (HCC). In infected hepatocytes, HBV DNA can be integrated into the host genome through an insertional mutagenesis process inducing tumorigenesis. Dissection of the genomic features surrounding integration sites will deepen our understanding of mechanisms underlying integration. Moreover, the...

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PMID: 34221926
DOI: 10.14218/jcth.2021.00062

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