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Article

Cardiovascular safety of genetically proxied interleukin-5 inhibition: A mendelian randomization study.

Respiratory investigation - 1 Mar 2023

Alton Philip, Hughes David M, Zhao Sizheng Steven

Abstract excerpt

Interleukin-5 (IL-5) inhibitors have revolutionized the management of eosinophilic asthma. However, IL-5 is thought to play a protective role in atherosclerosis, and cardiovascular safety data for IL-5i are scarce. We used population-level data to examine the association between genetically proxied IL-5i and the risk of cardiovascular diseases. Genetic instruments for IL-5i were selected from a genome-wide...

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Identifiers

PMID: 36682083
DOI: 10.1016/j.resinv.2022.12.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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