Genetic loci on chromosome 5 are associated with circulating levels of interleukin-5 and eosinophil count in a European population with high risk for cardiovascular disease.

doi:10.1016/j.cyto.2016.01.007

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Article

Genetic loci on chromosome 5 are associated with circulating levels of interleukin-5 and eosinophil count in a European population with high risk for cardiovascular disease.

Cytokine - 1 May 2016

McLeod Olga, Silveira Angela, Valdes-Marquez Elsa, Björkbacka Harry, Almgren Peter, Gertow Karl, Gådin Jesper R, Bäcklund Alexandra, Sennblad Bengt, Baldassarre Damiano, Veglia Fabrizio, Humphries Steve E, Tremoli Elena, de Faire Ulf, Nilsson Jan, Melander Olle, Hopewell Jemma C, Clarke Robert, Björck Hanna M, Hamsten Anders, Öhrvik John, Strawbridge Rona J

Abstract excerpt

IL-5 is a Th2 cytokine which activates eosinophils and is suggested to have an atheroprotective role. Genetic variants in the IL5 locus have been associated with increased risk of CAD and ischemic stroke. In this study we aimed to identify genetic variants associated with IL-5 concentrations and apply a Mendelian randomisation approach to assess IL-5 levels for causal effect on intima-media thickness in a...

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PMID: 26821299
DOI: 10.1016/j.cyto.2016.01.007
PMCID: PMC4837217

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RAD50
CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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