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Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium

1 Jan 2023

Abstract excerpt

The SARS-CoV-2 Omicron variant of concern (VoC) and its sublineages contain 31-36 mutations in spike and escape neutralization by most therapeutic antibodies. In a pseudovirus neutralization assay, 66 of the nearly 400 candidate therapeutics in the Coronavirus Immunotherapeutic Consortium (CoVIC) panel neutralize Omicron and multiple Omicron sublineages. Among natural immunoglobulin Gs (IgGs), especially those in...

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PMID: 36681898
DOI: 10.1016/j.celrep.2023.112014

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