Article

SARS-CoV-2 Omicron potently neutralized by a novel antibody with unique Spike binding properties

2022-03-18

Abstract excerpt

The SARS-CoV-2 Omicron variant exhibits very high levels of transmission, pronounced resistance to authorized therapeutic human monoclonal antibodies and reduced sensitivity to vaccine-induced immunity. Here we describe P2G3, a human monoclonal antibody (mAb) isolated from a previously infected and vaccinated donor, which displays picomolar-range neutralizing activity against Omicron BA.1, BA.1.1, BA.2 and all oth...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de66a6ab-8050-5dc7-a0fa-5320f5bd000b
DOI: 10.1101/2022.03.18.484873

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 Omicron potently neutralized by a novel antibody with unique Spike binding propertiesDOI 10.1101/2022.03.18.484873Read

Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeysSemantic proximity Read

Structural insights for neutralization of BA.1 and BA.2 Omicron variants by a broadly neutralizing SARS-CoV-2 antibodySemantic proximity Read

A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of ConcernSemantic proximity Read

Production of a monoclonal antibody targeting the SARS-CoV-2 Omicron spike protein and analysis of SARS-CoV-2 Omicron mutations related to monoclonal antibody resistance.Semantic proximity Read

Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variantsSemantic proximity Read

A potent SARS-CoV-2 antibody neutralizes Omicron variant by disassembling the spike trimerSemantic proximity Read

Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domainSemantic proximity Read

Neutralization of SARS-CoV-2 Omicron BA.2 by Therapeutic Monoclonal AntibodiesSemantic proximity Read

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineagesSemantic proximity Read

Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortiumSemantic proximity Read

Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike TrimerSemantic proximity Read

A human monoclonal antibody neutralizing SARS-CoV-2 Omicron variants containing the L452R mutation.Semantic proximity Read