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Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines

19 Jul 2022

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide. We show that the large number of Omicron sublineage spike mutations leads to enhanced angiotensin-converting enzyme 2 (ACE2) binding, reduced fusogenicity, and...

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PMID: 35857529
DOI: 10.1126/science.abq0203

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