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Article

Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle.

Toxicology - 3 Jul 2014

Kojima Shuji, Negishi Yusuke, Tsukimoto Mitsutoshi, Takenouchi Takato, Kitani Hiroshi, Takeda Ken

Abstract excerpt

There is extensive evidence that nanoparticles (NPs) cause adverse effects in multiple organs, including liver, though the mechanisms involved remain to be fully established. Kupffer cells are macrophages resident in the liver, and play important roles in liver inflammation induced by various toxic agents, including lipopolysaccharide (LPS). Interleukin-1 (IL-1) family members IL-1α,β are released from LPS-primed...

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Identifiers

PMID: 24685903
DOI: 10.1016/j.tox.2014.03.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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