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Article

Presenilin 1 Modulates Acetylcholinesterase Trafficking and Maturation.

International journal of molecular sciences - 11 Jan 2023

Cortés-Gómez María-Ángeles, Barberá Víctor M, Alom Jordi, Sáez-Valero Javier, García-Ayllón María-Salud

Abstract excerpt

In Alzheimer's disease (AD), the reduction in acetylcholinesterase (AChE) enzymatic activity is not paralleled with changes in its protein levels, suggesting the presence of a considerable enzymatically inactive pool in the brain. In the present study, we validated previous findings, and, since inactive forms could result from post-translational modifications, we analyzed the glycosylation of AChE by lectin...

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Identifiers

PMID: 36674948
DOI: 10.3390/ijms24021437
PMCID: PMC9864477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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