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Recent advances toward a molecular mechanism of efflux pump inhibition

5 May 2015

Abstract excerpt

Multidrug resistance (MDR) in Gram-negative pathogens, such as the Enterobacteriaceae and Pseudomonas aeruginosa, poses a significant threat to our ability to effectively treat infections caused by these organisms. A major component in the development of the MDR phenotype in Gram-negative bacteria is overexpression of Resistance-Nodulation-Division (RND)-type efflux pumps, which actively pump antibacterial agents...

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Share to Antibiotic Resistance in Bacteria
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PMID: 25999939
DOI: 10.3389/fmicb.2015.00421

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