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Article

Efflux Pumps of Gram-Negative Bacteria, a New Target for New Molecules

1 Dec 2010

Abstract excerpt

Antibiotic resistance mechanisms reported in Gram-negative bacteria are a worldwide health problem. The continuous dissemination of multi-drug resistant (MDR) bacteria drastically reduces the efficacy of our antibiotic “arsenal” and consequently increases the frequency of therapeutic failure. In MDR bacteria the over-expression of efflux pumps expel structurally-unrelated antibiotics decreasing their...

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PMID: 20615189
DOI: 10.2174/156802610793176620

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