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Article

Antibiotic efflux pumps in Gram-negative bacteria: the inhibitor response strategy

17 Jan 2007

Abstract excerpt

After several decades of continuously successful antibiotic therapy against bacterial infections, we are now facing a worrying prospect: the accelerated evolution of antibiotic resistance to important human pathogens and the scarcity of new anti-infective drug families under development. Efflux is a general mechanism responsible for bacterial resistance to antibiotics. This active drug transport is involved in...

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PMID: 17229832
DOI: 10.1093/jac/dkl493

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Source receipt: pubmed, retrieved 7 Sept 2026.

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