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Article

Single-tube multiplex real-time PCR assay for rapid and reliable detection of HLA-A*31:01 allele.

Pharmacogenomics - 1 Jul 2018

Zhang Tingting, Xiao Ying, Wang Yanxia, Li Yanwei, Zhang Lirong, Chen Chao, Wang Huijuan

Abstract excerpt

AIM: HLA-A*31:01 has been associated with carbamazepine-induced hypersensitivity reactions. HLA-A*31:01 genetic testing is recommended before the initiation of carbamazepine therapy. METHODS: A novel real-time PCR assay was designed for HLA-A*31:01 detection by allele-specific primers and TaqMan minor groove binding probes. RESULTS: The genotyping results in 100 subjects by the established method who were in 100%...

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Identifiers

PMID: 29925289
DOI: 10.2217/pgs-2018-0050

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