Article
Validation of a novel real-time PCR assay for detection of HLA-B*15:02 allele for prevention of carbamazepine - Induced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis in individuals of Asian ancestry.
Human immunology - 1 Dec 2016
Nguyen Dinh Van, Vidal Christopher, Chu Hieu Chi, Do Nga Thi Quynh, Tran Tu Thi Linh, Le Huong Thi Minh, Fulton Richard B, Li Jamma, Fernando Suran L
Abstract excerpt
OBJECTIVES: Screening for the HLA-B*15:02 allele has been recommended to prevent carbamazepine (CBZ) - induced Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in individuals with Asian ancestry. We aimed, therefore, to develop and validate a robust and inexpensive method for detection of the HLA-B*15:02 allele. METHODS: Real-time PCR using TaqMan® probes followed by SYBR® Green was used to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.