Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In Silico Mutational Analysis of Two-Component System Genes Associated with Colistin Resistance in Clinical Pseudomonas aeruginosa Isolates from Peshawar.

Biomolecules - 29 Jun 2026

Ahmad Bashir, Ali Qaisar, Azam Sadiq, Asghar Muhammad, Rehman Noor, Mujib Gul-E-Sehra, Shah Syed Sohail, Javed Jamila, Khan Ibrar, Khan Taj Ali, Clark Taane G

Abstract excerpt

Pseudomonas aeruginosa is an opportunistic pathogen causing healthcare-associated infections. Colistin is a last-resort antibiotic for multidrug-resistant Gram-negative bacteria. Resistance arises through mutations in two-component systems (TCS) regulating the arn operon. Data on colistin resistance in P. aeruginosa from Pakistan remain limited. A total of 3189 clinical samples (urine, blood, sputum, pus, wound...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colistin

Share to Computer Simulation

Share to Drug Resistance, Bacterial

Share to Microbial Sensitivity Tests

Share to Molecular Docking Simulation

Share to Pseudomonas aeruginosa

Source

Open in PubMed Open full text

Identifiers

PMID: 42509756
DOI: 10.3390/biom16070962
PMCID: PMC13406812

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In Silico Mutational Analysis of Two-Component System Genes Associated with Colistin Resistance in Clinical Pseudomonas aeruginosa Isolates from Peshawar.PMID 42509756Read ↗

Mutations in two component system (PhoPQ and PmrAB) in colistin resistant Klebsiella pneumoniae from North Indian tertiary care hospital.Semantic proximity Read ↗

Molecular characteristics of chromosome-mediated colistin resistance in carbapenem-resistant Pseudomonas aeruginosa isolates from a tertiary hospital in China.Semantic proximity Read ↗

Genome-wide analyses reveal antibiotic resistance genes and mechanisms in pathogenic Pseudomonas bacteriaSemantic proximity Read ↗

Genomic investigation unveils colistin resistance mechanism in carbapenem-resistant Acinetobacter baumannii clinical isolatesSemantic proximity Read ↗

Qualitative analysis of genomic mutations and antibiotic susceptibility testing of Pseudomonas aeruginosa isolates from chronic lung infections.Semantic proximity Read ↗

Comparative genomics of colistin-nonsusceptible multidrug-resistant Pseudomonas aeruginosa reveals emerging lineages in Thailand.Semantic proximity Read ↗

Impact of Two-Component Regulatory Systems PhoP-PhoQ and PmrA-PmrB on Colistin Pharmacodynamics in Pseudomonas aeruginosaSemantic proximity Read ↗

Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics.Semantic proximity Read ↗

Current Update on Intrinsic and Acquired Colistin Resistance Mechanisms in BacteriaSemantic proximity Read ↗

Mutations at Novel Sites in pmrA/B and lpxA/D Genes and Absence of Reduced Fitness in Colistin-Resistant Acinetobacter baumannii from a Tertiary Care Hospital, India.Semantic proximity Read ↗

Transposon insertion sequencing of <i>Pseudomonas aeruginosa</i> identifies multiple intersecting pathways essential for extreme colistin resistanceSemantic proximity Read ↗

Plasmid-mediated mcr-1 gene in Acinetobacter baumannii and Pseudomonas aeruginosa: first report from PakistanSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.