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Article

BRAF-V600E expression in primary nodular melanoma is associated with aggressive tumour features and reduced survival.

British journal of cancer - 29 Mar 2016

Hugdahl Emilia, Kalvenes May Britt, Puntervoll Hanne E, Ladstein Rita G, Akslen Lars A

Abstract excerpt

BACKGROUND: Around 50% of primary melanomas harbour BRAF mutations, but their prognostic impact has not been clear. Recently, a BRAF-V600E mutation-specific antibody has become available for immunohistochemistry. Here, we investigated for the first time the prognostic impact of BRAF-V600E protein expression in primary melanoma. METHODS: In a patient series of 248 nodular melanomas, BRAF-V600E and total BRAF...

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Share to Immunoenzyme Techniques
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma, Cutaneous Malignant

Share to Proto-Oncogene Proteins B-raf

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Source

Open in PubMed Open full text

Identifiers

PMID: 26924424
DOI: 10.1038/bjc.2016.44
PMCID: PMC4984864

Genes

BRAF

Variants

Provenance

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