Article

Fitness and immune-escape within germinal centers shape premalignant evolution toward lymphoma

2026-06-26

Abstract excerpt

<h4>Summary</h4> Germinal centers (GCs) support physiological B-cell mutagenesis and are considered lymphoma-permissive; nevertheless, lymphoma development is uncommon. Human in situ follicular neoplasia (ISFN) captures this paradox: premalignant B-cells can persist within GCs for prolonged periods without progressing to overt lymphoma. We found that human ISFN, but not normal GCs, are infiltrated by CD8⁺ T-cell...

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Literature Corpus work: 82f8599b-45ce-5786-8ed5-354dacb35fa4
DOI: 10.64898/2026.06.25.734549

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