Article
Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases.
Nature medicine - 1 Jan 2023
Kiiskinen Tuomo, Helkkula Pyry, Krebs Kristi, Karjalainen Juha, Saarentaus Elmo, Mars Nina, Lehisto Arto, Zhou Wei, Cordioli Mattia, Jukarainen Sakari, Rämö Joel T, Mehtonen Juha, Veerapen Kumar, Räsänen Markus, Ruotsalainen Sanni, Maasha Mutaamba, Niiranen Teemu, Tuomi Tiinamaija, Salomaa Veikko, Kurki Mitja, Pirinen Matti, Palotie Aarno, Daly Mark, Ganna Andrea, Havulinna Aki S, Milani Lili, Ripatti Samuli
Abstract excerpt
Little is known about the genetic determinants of medication use in preventing cardiometabolic diseases. Using the Finnish nationwide drug purchase registry with follow-up since 1995, we performed genome-wide association analyses of longitudinal patterns of medication use in hyperlipidemia, hypertension and type 2 diabetes in up to 193,933 individuals (55% women) in the FinnGen study. In meta-analyses of up to...
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