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Biobank scale pharmacogenomics informs the genetic underpinnings of simvastatin use

2020-11-24

Abstract excerpt

<h4>Background and Purpose</h4> Studying drug metabolizing enzymes, encoded by pharmacogenes (PGx), may inform biological mechanisms underlying the diseases for which a medication is prescribed. Until recently, PGx loci could not be studied at biobank scale. Here we analyze PGx haplotype variation to detect associations with medication use in the UK Biobank. <h4>Methods</h4> In 7,649 unrelated African-ancestry (AF...

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Literature Corpus work
ca956b67-574b-529d-adbd-f33d3e204f21
DOI
10.1101/2020.11.23.20235846
Open publication

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Biobank scale pharmacogenomics informs the genetic underpinnings of simvastatin useDOI 10.1101/2020.11.23.20235846
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