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Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape

18 Jan 2023

Abstract excerpt

Waves of SARS-CoV-2 infection have resulted from the emergence of viral variants with neutralizing antibody resistance mutations. Simultaneously, repeated antigen exposure has generated affinity matured B cells, producing broadly neutralizing receptor binding domain (RBD)-specific antibodies with activity against emergent variants. To determine how SARS-CoV-2 might escape these antibodies, we subjected chimeric...

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PMID: 36653360
DOI: 10.1038/s41467-023-35927-0

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