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Article

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution.

Science (New York, N.Y.) - 22 Jul 2022

Starr Tyler N, Greaney Allison J, Hannon William W, Loes Andrea N, Hauser Kevin, Dillen Josh R, Ferri Elena, Farrell Ariana Ghez, Dadonaite Bernadeta, McCallum Matthew, Matreyek Kenneth A, Corti Davide, Veesler David, Snell Gyorgy, Bloom Jesse D

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved variants with substitutions in the spike receptor-binding domain (RBD) that affect its affinity for angiotensin-converting enzyme 2 (ACE2) receptor and recognition by antibodies. These substitutions could also shape future evolution by modulating the effects of mutations at other sites-a phenomenon called epistasis. To investigate this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35762884
DOI: 10.1126/science.abo7896
PMCID: PMC9273037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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