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Article

A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function

17 Jan 2023

Abstract excerpt

To fertilize an oocyte, the membrane potential of both mouse and human sperm must hyperpolarize (become more negative inside). Determining the molecular mechanisms underlying this hyperpolarization is vital for developing new contraceptive methods and detecting causes of idiopathic male infertility. In mouse sperm, hyperpolarization is caused by activation of the sperm-specific potassium (K + ) channel SLO3 [C....

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PMID: 36649421
DOI: 10.1073/pnas.2212338120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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