Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homozygous mutation in SLO3 leads to severe asthenoteratozoospermia due to acrosome hypoplasia and mitochondrial sheath malformations

3 Jan 2022

Abstract excerpt

BACKGROUND: Potassium channels are important for the structure and function of the spermatozoa. As a potassium transporter, the mSlo3 is essential for male fertility as Slo3 knockout male mice were infertile with the series of functional defects in sperm cells. However, no pathogenic variant has been detected in human SLO3 to date. Here we reported a human case with homozygous SLO3 mutation. The function of SLO3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ion channel regulation and function
Share to Ion Transport and Channel Regulation
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34980136
DOI: 10.1186/s12958-021-00880-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homozygous mutation in SLO3 leads to severe asthenoteratozoospermia due to acrosome hypoplasia and mitochondrial sheath malformationsPMID 34980136Read ↗

SLO3: A Conserved Regulator of Sperm Membrane PotentialSemantic proximity Read ↗

SLO3: A Conserved Regulator of Sperm Membrane PotentialSemantic proximity Read ↗

A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm functionSemantic proximity Read ↗

Novel biallelic mutations in SLC26A8 cause severe asthenozoospermia in humans owing to midpiece defects: Insights into a putative dominant genetic disease.Semantic proximity Read ↗

Homozygous variants in AKAP3 induce asthenoteratozoospermia and male infertility.Semantic proximity Read ↗

A genetic variant of the sperm-specific SLO3 K+ channel has altered pH and Ca2+ sensitivities.Semantic proximity Read ↗

Biallelic loss‐of‐function mutations in SEPTIN4 ( C17ORF47 ), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in humansSemantic proximity Read ↗

SPEM1 Gene Mutation in a Case with Sperm Morphological Defects Leading to Male Infertility.Semantic proximity Read ↗

Novel frameshift mutation in STK33 is associated with asthenozoospermia and multiple morphological abnormalities of the flagella.Semantic proximity Read ↗

Loss of SPACA1 function causes autosomal recessive globozoospermia by damaging the acrosome–acroplaxome complexSemantic proximity Read ↗

A recurrent homozygous missense mutation in CCDC103 causes asthenoteratozoospermia due to disorganized dynein arms.Semantic proximity Read ↗

Human sperm ion channel (dys)function: implications for fertilizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.