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Article

Slo1 is the principal potassium channel of human spermatozoa

8 Oct 2013

Abstract excerpt

Mammalian spermatozoa gain competence to fertilize an oocyte as they travel through the female reproductive tract. This process is accompanied by an elevation of sperm intracellular calcium and a membrane hyperpolarization. The latter is evoked by K(+) efflux; however, the molecular identity of the potassium channel of human spermatozoa (hKSper) is unknown. Here, we characterize hKSper, reporting that it is...

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PMID: 24137539
DOI: 10.7554/elife.01009

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