Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genetic variant of the sperm-specific SLO3 K+ channel has altered pH and Ca2+ sensitivities.

The Journal of biological chemistry - 26 May 2017

Geng Yanyan, Ferreira Juan J, Dzikunu Victor, Butler Alice, Lybaert Pascale, Yuan Peng, Magleby Karl L, Salkoff Lawrence, Santi Celia M

Abstract excerpt

To fertilize an oocyte, sperm must first undergo capacitation in which the sperm plasma membrane becomes hyperpolarized via activation of potassium (K+) channels and resultant K+ efflux. Sperm-specific SLO3 K+ channels are responsible for these membrane potential changes critical for fertilization in mouse sperm, and they are only sensitive to pH i However, in human sperm, the major K+ conductance is both Ca2+-...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Fertility

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrogen-Ion Concentration

Share to Ion Channel Gating

Share to Large-Conductance Calcium-Activated Potassium Channel alpha Subunits

Share to Large-Conductance Calcium-Activated Potassium Channels

Share to Potassium Channels, Voltage-Gated

Share to Spermatozoa

Source

Open in PubMed Open full text

Identifiers

PMID: 28377504
DOI: 10.1074/jbc.M117.776013
PMCID: PMC5448129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genetic variant of the sperm-specific SLO3 K+ channel has altered pH and Ca2+ sensitivities.PMID 28377504Read ↗

SLO3: A Conserved Regulator of Sperm Membrane PotentialSemantic proximity Read ↗

SLO3: A Conserved Regulator of Sperm Membrane PotentialSemantic proximity Read ↗

Ion permeabilities in mouse sperm reveal an external trigger for SLO3-dependent hyperpolarization.Semantic proximity Read ↗

SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility.Semantic proximity Read ↗

Homozygous mutation in SLO3 leads to severe asthenoteratozoospermia due to acrosome hypoplasia and mitochondrial sheath malformationsSemantic proximity Read ↗

The Control of Male Fertility by Spermatozoan Ion ChannelsSemantic proximity Read ↗

A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm functionSemantic proximity Read ↗

Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.Semantic proximity Read ↗

Ion channels that control fertility in mammalian spermatozoaSemantic proximity Read ↗

Human sperm ion channel (dys)function: implications for fertilizationSemantic proximity Read ↗

Slo1 is the principal potassium channel of human spermatozoaSemantic proximity Read ↗

Corneal dystrophy mutations R125H and R804H disable SLC4A11 by altering the extracellular pH dependence of the intracellular pK that governs H+(OH-) transport.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.