Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of Sialic Acid-Binding Immunoglobulin-Like Lectin 15 With Phenotypes in Esophageal Squamous Cell Carcinoma in the Setting of Neoadjuvant Chemoradiotherapy.

JAMA network open - 3 Jan 2023

Zhou Sha, Wang Yuting, Zhang Rui, Zeng Weian, Liu Shiliang, Liu Songran, Liu Mengzhong, Yang Hong, Xi Mian

Abstract excerpt

Importance: Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a novel immune checkpoint molecule that is highly homologous to programmed cell death ligand 1 (PD-L1), but information remains limited about its role in esophageal squamous cell carcinoma (ESCC). Objective: To explore the expression pattern and association of Siglec-15 with outcomes among patients with ESCC who received neoadjuvant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B7-H1 Antigen
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Esophageal Neoplasms

Share to Esophageal Squamous Cell Carcinoma

Share to Immunoglobulins

Share to N-Acetylneuraminic Acid

Share to Neoadjuvant Therapy

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 36648946
DOI: 10.1001/jamanetworkopen.2022.50965
PMCID: PMC9856737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Sialic Acid-Binding Immunoglobulin-Like Lectin 15 With Phenotypes in Esophageal Squamous Cell Carcinoma in the Setting of Neoadjuvant Chemoradiotherapy.PMID 36648946Read ↗

Comprehensive Analysis of SIGLEC-15 and PD-L1 Expression Identifies Distinct Prognostic Profiles in Gastric CancerSemantic proximity Read ↗

Identification and characterization of three Siglec15-related immune and prognostic subtypes of breast-invasive cancer.Semantic proximity Read ↗

Siglec15 in blood system diseases: from bench to bedsideSemantic proximity Read ↗

A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by affecting tumor associated macrophagesSemantic proximity Read ↗

Unveiling the molecular features, relevant immune and clinical characteristics of SIGLEC15 in thyroid cancerSemantic proximity Read ↗

Siglec-15 as an Emerging Target for Next-generation Cancer ImmunotherapySemantic proximity Read ↗

Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec‐15 axis in immune escapeSemantic proximity Read ↗

ISG15 upregulation characterizes a PD-L1-associated immunosuppressive phenotype with CD8+ T-cell dysfunction in hepatocellular carcinoma.Semantic proximity Read ↗

Evaluation of GDF15 Significance as a Biomarker in Laryngeal Squamous Cell CarcinomaSemantic proximity Read ↗

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockadeSemantic proximity Read ↗

ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive systemSemantic proximity Read ↗

Siglec-15 expression in diffuse glioma and its correlation with MRI morphologic features and ADCSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.