Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and characterization of three Siglec15-related immune and prognostic subtypes of breast-invasive cancer.

International immunopharmacology - 1 May 2022

Cao Xi, Zhou Yidong, Mao Feng, Lin Yan, Zhou Xingtong, Sun Qiang

Abstract excerpt

Sialic acid-binding immunoglobulin-like lectin 15 (Siglec15) is an immune checkpoint molecule that can inhibit T cell proliferation and have anti-tumor immunity. We explored the correlation between Siglct15 and the clinical features, mutation frequency, and prognosis of breast cancer. 122 upregulated and 11 downregulated genes between Siglet15-high and -low expression groups of 1109 breast invasive cancer samples...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B7-H1 Antigen
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Immunoglobulins

Share to Membrane Proteins

Share to Mutation

Share to Prognosis

Source

Identifiers

PMID: 35151947
DOI: 10.1016/j.intimp.2022.108561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and characterization of three Siglec15-related immune and prognostic subtypes of breast-invasive cancer.PMID 35151947Read ↗

Unveiling the molecular features, relevant immune and clinical characteristics of SIGLEC15 in thyroid cancerSemantic proximity Read ↗

Siglec15 in blood system diseases: from bench to bedsideSemantic proximity Read ↗

Siglec-15 as an Emerging Target for Next-generation Cancer ImmunotherapySemantic proximity Read ↗

Association of Sialic Acid-Binding Immunoglobulin-Like Lectin 15 With Phenotypes in Esophageal Squamous Cell Carcinoma in the Setting of Neoadjuvant Chemoradiotherapy.Semantic proximity Read ↗

Glycosylation of Tetraspanin CD151 Defines the Invasive Phenotype of Human Breast Cancer Cells.Semantic proximity Read ↗

Integrative Analysis of Siglec-15 mRNA in Human Cancers Based on Data MiningSemantic proximity Read ↗

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samplesSemantic proximity Read ↗

Comprehensive Analysis of SIGLEC-15 and PD-L1 Expression Identifies Distinct Prognostic Profiles in Gastric CancerSemantic proximity Read ↗

The Expression Pattern and Clinical Significance of the Immune Checkpoint Regulator VISTA in Human Breast CancerSemantic proximity Read ↗

Development of a 15-Gene Signature Model as a Prognostic Tool in Sex Hormone-Dependent Cancers.Semantic proximity Read ↗

Molecular structure, expression, and the emerging role of Siglec‐15 in skeletal biology and cancerSemantic proximity Read ↗

Elevated transcription and glycosylation of B3GNT5 promotes breast cancer aggressivenessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.