Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive Analysis of SIGLEC-15 and PD-L1 Expression Identifies Distinct Prognostic Profiles in Gastric Cancer

5 Sept 2025

Abstract excerpt

Gastric cancer remains a major global health burden, with limited response rates to current immunotherapies targeting the programmed death-ligand 1 (PD-1/PD-L1) axis. Recent studies have identified sialic acid-binding immunoglobulin-like lectin 15 (SIGLEC-15) as a novel immune checkpoint molecule that may drive immune evasion through PD-L1–independent pathways. This study aimed to evaluate the expression patterns...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune Cell Function and Interaction
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40943560
DOI: 10.3390/ijms26178637

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive Analysis of SIGLEC-15 and PD-L1 Expression Identifies Distinct Prognostic Profiles in Gastric CancerPMID 40943560Read ↗

Association of Sialic Acid-Binding Immunoglobulin-Like Lectin 15 With Phenotypes in Esophageal Squamous Cell Carcinoma in the Setting of Neoadjuvant Chemoradiotherapy.Semantic proximity Read ↗

Siglec15 in blood system diseases: from bench to bedsideSemantic proximity Read ↗

Siglec-15 as an Emerging Target for Next-generation Cancer ImmunotherapySemantic proximity Read ↗

Identification and characterization of three Siglec15-related immune and prognostic subtypes of breast-invasive cancer.Semantic proximity Read ↗

High PD-L1 expression in gastric cancer (GC) patients and correlation with molecular featuresSemantic proximity Read ↗

Utility of GDF ‐15 as a diagnostic biomarker in gastric cancer: an investigation combining GEO , TCGA and meta‐analysisSemantic proximity Read ↗

Genetic variants of CD160, MERTK, and IL15 in natural killer cell-related pathway predict gastric cancer survival.Semantic proximity Read ↗

Integrative Analysis of Siglec-15 mRNA in Human Cancers Based on Data MiningSemantic proximity Read ↗

Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic PerspectivesSemantic proximity Read ↗

CD151—A Striking Marker for Cancer TherapySemantic proximity Read ↗

Molecular structure, expression, and the emerging role of Siglec‐15 in skeletal biology and cancerSemantic proximity Read ↗

Evaluation of GDF15 Significance as a Biomarker in Laryngeal Squamous Cell CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.