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Article

Siglec-15 as an Emerging Target for Next-generation Cancer Immunotherapy

21 Sept 2020

Abstract excerpt

Immunomodulatory agents blocking the PD-1/PD-L1 pathway have shown a new way to treat cancer. The explanation underlying the success of these agents may be the selective expression of PD-L1 with dominant immune-suppressive activities in the tumor microenvironment (TME), supporting a more favorable tumor response-to-toxicity ratio. However, despite the big success of these drugs, most patients with cancer show...

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PMID: 32958700
DOI: 10.1158/1078-0432.ccr-19-2925

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