Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2.

Clinical cancer research : an official journal of the American Association for Cancer Research - 3 Apr 2023

Liu Yang, Chou Fu-Ju, Lang Fengchao, Zhang Meili, Song Hua, Zhang Wei, Davis Dionne L, Briceno Nicole J, Zhang Yang, Cimino Patrick J, Zaghloul Kareem A, Gilbert Mark R, Armstrong Terri S, Yang Chunzhang

Abstract excerpt

PURPOSE: Mutations of the isocitrate dehydrogenase (IDH) gene are common genetic mutations in human malignancies. Increasing evidence indicates that IDH mutations play critical roles in malignant transformation and progression. However, the therapeutic options for IDH-mutated cancers remain limited. In this study, the investigation of patient cohorts revealed that the PI3K/protein kinase B (AKT) signaling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Proto-Oncogene Proteins c-akt
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferroptosis

Share to Glioma

Share to Isocitrate Dehydrogenase

Share to NF-E2-Related Factor 2

Share to Phosphatidylinositol 3-Kinases

Share to Temozolomide

Source

Open in PubMed Open full text

Identifiers

PMID: 36648507
DOI: 10.1158/1078-0432.CCR-22-3179
PMCID: PMC10073324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2.PMID 36648507Read ↗

Regulation of ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancerSemantic proximity Read ↗

Mutant IDH1 inhibits PI3K/Akt signaling in human glioma.Semantic proximity Read ↗

A Novel Prognostic Signature Based on Glioma Essential Ferroptosis-Related Genes Predicts Clinical Outcomes and Indicates Treatment in GliomaSemantic proximity Read ↗

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.Semantic proximity Read ↗

Efficacy and safety of IDH inhibitors in IDH-mutated cancers: a systematic review and meta-analysis of 4 randomized controlled trials.Semantic proximity Read ↗

IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced.Semantic proximity Read ↗

Flavopiridol Suppresses Cell Proliferation and Migration and Induces Apoptotic Cell Death by Inhibiting Oncogenic FOXM1 Signaling in IDH Wild-Type and IDH-Mutant GBM Cells.Semantic proximity Read ↗

Why All the Fuss about Oxidative Phosphorylation (OXPHOS)?Semantic proximity Read ↗

Apatinib Induces Ferroptosis of Glioma Cells through Modulation of the VEGFR2/Nrf2 PathwaySemantic proximity Read ↗

PNKP targeting engages the autophagic machinery through STING and STAT3 to potentiate ferroptosis and chemotherapy in TNBCSemantic proximity Read ↗

Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism.Semantic proximity Read ↗

Prohibitin2 knockdown decreases glioma malignant phenotypes and radio-resistance by inhibiting mitophagy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.